Interfacial elastic relaxation during the ejection of bi-layered tablets

Area of Science:

• Pharmaceutical Sciences
• Materials Science

Background:

• Bi-layered tablets are used for controlled drug release but often fail at the interface.
• Understanding interfacial bond weakening is crucial for improving tablet mechanical integrity.

Purpose of the Study:

• To investigate the mechanisms behind interfacial bond weakening in bi-layered tablets.
• To determine how interface strength affects mechanical integrity during compaction and ejection.

Main Methods:

• Compaction and ejection simulation of bi-layered tablets.
• Analysis of elastic relaxation in the interface region.
• Correlation of interface strength with plastic bonding and elastic recovery.

Main Results:

• Elastic relaxation in the interface region decreases as bi-layered tablet interface strength increases.
• Increased plastic bonding in the interface region is associated with reduced elastic relaxation.
• Tablet diametrical elastic relaxation influences tablet height elastic relaxation.

Conclusions:

• Enhancing interfacial bonding through increased plastic deformation improves the mechanical integrity of bi-layered tablets.
• Controlling elastic relaxation during ejection is vital for robust controlled release drug delivery systems.
• The study provides fundamental insights into optimizing bi-layered tablet design for pharmaceutical applications.