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Gastroprotective activity of Trichosanthes cucumerina in rats
L D A M Arawwawala1, M I Thabrew, L S R Arambewela
1Industrial Technology Institute, Bauddhaloka Mawatha, Colombo, Sri Lanka. menuka@iti.lk
Aim Of The Study:
The aim of the present study was to scientifically investigate whether Trichosanthes cucumerina Linn (Family: Cucurbitaceae) has gastroprotective activity.
Materials And Methods:
All the experiments were conducted using Wistar strain rats (weight: 200-220 g). The food and water given to rats was withdrawn for 36 and 12h respectively, before the commencement of the experiment. These rats were randomly divided into 6 groups (n=8 rats/group; 4 males+4 females) and groups 1-3 were orally administrated with hot water extract (HWE) at a dose of 375, 500 and 750 mg/kg, respectively. Group 4 was orally treated with equal volume of distilled water (1 mL; control), group 5 was orally treated with a reference drug, cimetidine (100mg/kg) while the group 6 was orally treated with another reference drug, sucralfate (400mg/kg). In the indomethacin experiment, only one dose of HWE (750 mg/kg) was tested, as this was found to have the maximum effect in the alcohol model also.
Results:
Results show that the HWE of Trichosanthes cucumerina possesses significant (P
Conclusion:
It may be concluded that HWE of Trichosanthes cucumerina exerts a significant protection against ethanol or indomethacin induced gastric damage. Increasing the protective mucus layer, decreasing the acidity of the gastric juice and antihistamine activity are probable mechanisms by which the HWE of Trichosanthes cucumerina mediates its gastroprotective actions.
