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Updated: Jun 18, 2026

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
Published on: September 18, 2013
Elevations of creatine kinase in patients treated with imatinib mesylate (Gleevec)
Jessica K Gordon1, Steven K Magid, Robert G Maki
1Department of Rheumatology, Hospital for Special Surgeryy, New York, NY 10021, USA. gordonj@hss.edu
Abstract:
Imatinib mesylate is used with increasing frequency and duration for the treatment of chronic myelogenous leukemia (CML), gastrointestinal stromal tumor (GIST), and other neoplastic conditions. Although muscular complaints are common, elevations of creatine kinase (CK) are listed as <1% in the product label. We describe here a case of rhabdomyolysis likely related to imatinib as well as the results of a prospective evaluation of CK levels in a cohort of patients on imatinib for CML or GIST. We found a high prevalence of CK abnormalities in this group and believe that CKs should be monitored during therapy with imatinib.
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