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In vitro cytotoxicity testing and the application of elastic interconnection technology for short-term implantable
Dominique Brosteaux1, Evi Lippens, Ria Cornelissen
1CMST, IMEC/Ghent University, Gent-Zwijnaarde, Belgium. dominique.brosteaux@elis.ugent.be
Abstract:
An electronic device was fabricated consisting of 2 flexible electronic circuit islands, interconnected by a 7 cm long elastic interconnection, which could be elongated for at least 50%. This interconnection was based on gold conductor tracks following a 2-D spring pattern, embedded in a biocompatible silicone elastomer. The complete device was embedded in the same silicone elastomer. An in vitro cytotoxicity extraction test, executed on small test-samples in accordance with the ISO 10 993-1 guidelines, revealed that the applied silicone encapsulation to these samples functioned as a good seal for at least 8 days.
