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Electrophysiological Methods to Assess Peripheral Pain Block in an Anesthetized Rat
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Counted cycles method to quantify the onset response in high-frequency peripheral nerve block.

Emily L Foldes1, D Ackermann, Niloy Bhadra

  • 1Dept. of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA. eal20@case.edu

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
|December 8, 2009
PubMed
Summary

High frequency alternating current (HFAC) nerve block shows a two-phase onset response that needs independent elimination. HFAC can achieve a complete nerve block within 50-100 ms.

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Medical Devices

Background:

  • Clinical application of high frequency alternating current (HFAC) for peripheral nerve block is hindered by a significant nerve activity volley upon initiation.
  • This initial nerve activation, termed the 'onset response,' requires thorough characterization to enable effective HFAC nerve block.
  • Understanding and mitigating the onset response is crucial for advancing HFAC as a therapeutic tool.

Purpose of the Study:

  • To investigate and quantify the characteristics of the onset response during HFAC nerve block.
  • To determine if the onset response can be eliminated for improved clinical utility.
  • To establish the time course for achieving a complete nerve block with HFAC.

Main Methods:

  • Utilized an in-vivo animal model for preliminary experiments.
  • Employed counted cycles of HFAC to stimulate and record nerve activity.
  • Quantified the onset response and the time to achieve nerve block.

Main Results:

  • Demonstrated that the onset response comprises two distinct phases with unique characteristics.
  • Provided quantitative evidence for the biphasic nature of the initial nerve activation.
  • Confirmed that HFAC can establish a complete nerve block within a timeframe of 50-100 milliseconds.

Conclusions:

  • The onset response during HFAC nerve block has two independent phases requiring distinct mitigation strategies.
  • Eliminating the onset response is a key step towards optimizing HFAC for clinical nerve conduction block.
  • HFAC demonstrates potential for rapid and complete peripheral nerve blockade.