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A Pacing-Controlled Procedure for the Assessment of Heart Rate-Dependent Diastolic Functions in Murine Heart Failure Models
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A Pacing-Controlled Procedure for the Assessment of Heart Rate-Dependent Diastolic Functions in Murine Heart Failure Models

Published on: July 21, 2023

Heart sounds based measures of cardiac status for heart failure patient management

Abhilash Patangay1, Kris Z Siejko, Ramesh Wariar

  • 1Boston Scientific Corp., St. Paul, MN, USA. abhilash.patangay@bsci.com

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
|December 8, 2009
PubMed

Insights

Pacemaker-derived heart sound measurements, including S3 amplitude and systolic timing intervals (STIs), correlate with key heart failure metrics. These findings suggest potential for remote monitoring of cardiac function in heart failure patients.

Area of Science:

  • Cardiology
  • Biomedical Engineering
  • Medical Devices

Background:

  • Heart sounds, such as S3 amplitude and systolic timing intervals (STIs), are established indicators of cardiac dysfunction.
  • Pacemaker devices offer a platform for potentially monitoring cardiac health non-invasively.

Purpose of the Study:

  • To investigate the correlation between heart sound-based measurements obtained from pacemaker implant locations and echocardiographic hemodynamic metrics.
  • To assess the relationship between S3 amplitude, STIs, and E wave deceleration time (EDT), Ejection Fraction (EF), and Stroke Volume (SV).

Main Methods:

  • Simultaneous heart sound and echocardiography measurements were collected from 6 heart failure patients with cardiac resynchronization therapy (CRT) devices.
  • Data were gathered at baseline, and at 3 and 6 months post-CRT activation.
  • Statistical analysis, including correlation coefficients (r) and p-values, was used to determine relationships.

Main Results:

  • A significant negative correlation was found between S3 amplitude and EDT (r=-0.86, p<0.05).
  • Heart sound-based pre-ejection period (HSPEP) correlated with EF (r = -0.81, p<0.01), and heart sound ejection time (HSET) correlated with SV (r = 0.65, p=0.01).
  • Longitudinal analysis revealed consistent changes in these parameters over time, supporting their utility.

Conclusions:

  • Pacemaker-derived heart sound measurements demonstrate proof of concept for monitoring heart failure (HF) patients.
  • Further research is warranted to establish the efficacy of these measurements for chronic HF patient management.

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