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Cardiac ablation via electroporation.

Jinback Hong¹, Mark T Stewart, Daniel S Cheek

¹CardioVascular division of Medtronic, Inc., Fridley, MN 55432, USA. jinback.hong@medtronic.com

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

|December 8, 2009

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Electroporation offers a novel, non-thermal approach to cardiac ablation, overcoming limitations of traditional thermal methods. Early animal studies show promising lesion formation and transmurality, suggesting potential for treating arrhythmias.

Area of Science:

Cardiovascular Medicine
Biomedical Engineering
Electrophysiology

Background:

Thermal ablation for arrhythmias presents challenges like heat loss and tissue damage, impacting treatment success.
Existing thermal ablation methods can cause undesirable side effects due to excessive heat generation.

Purpose of the Study:

To introduce and evaluate electroporation as a novel, non-thermal ablation technique for cardiac arrhythmias.
To assess the feasibility and preliminary efficacy of a developed electroporation system in animal models.

Main Methods:

Development of a specialized system, tools, and methodology for operating the electroporation ablation technique.
Conducting preliminary in vivo acute animal studies using an ovine model.

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Main Results:

The electroporation technique demonstrated distinct lesion morphology in acute animal studies.
High success rates in achieving transmurality were observed, indicating potential for cardiac applications.
Electroporation induced cellular death via pore formation without significant negative thermal effects.

Conclusions:

Electroporation presents a viable non-thermal alternative for cardiac ablation, addressing limitations of thermal methods.
Preliminary findings support the potential of electroporation for treating cardiac arrhythmias.
Further long-term studies are required to confirm lesion durability and clinical adoption.