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Modeling current pathways for therapeutic electrical applications.

Robert Patterson1, Fei Yang

  • 1University of Minnesota, 420 Delaware St., MMC 297, Minneapolis MN 55455, USA. patte001@umn.edu

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
|December 8, 2009
PubMed
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A computer model of the human body was created to understand electrical current flow during medical therapies. This research highlights the importance of whole-body conductivity for accurate current pathway prediction in the heart.

Area of Science:

  • Biomedical Engineering
  • Computational Modeling
  • Medical Physics

Background:

  • Understanding current flow, density, and voltage gradients is crucial for therapeutic electrical devices.
  • Accurate modeling is needed to predict current distribution in targeted and surrounding tissues.

Purpose of the Study:

  • To develop a high-resolution, computer-based model for analyzing electrical current pathways.
  • To create a user-friendly graphical interface for a PC program to visualize these pathways.
  • To demonstrate the model's utility in studying electrical therapies like pacing and defibrillation.

Main Methods:

  • A high-resolution (3.8 million elements) finite difference model was created.
  • The model utilized gated electrocardiogram (ECG) magnetic resonance imaging (MRI) data from an adult male.

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  • A graphical user interface (GUI) was developed for a personal computer (PC) program.

    • Main Results:

    • The model successfully simulated current pathways, densities, and voltage gradients.
    • The developed GUI provides a user-friendly platform for analyzing electrical therapies.
    • Simulations demonstrated that the conductivity of the entire thorax significantly influences current pathways within the heart.

    Conclusions:

    • The developed computational model provides essential data for designing and optimizing therapeutic electrical devices.
    • The study underscores the critical role of whole-thorax conductivity in accurately predicting cardiac current flow.
    • The user-friendly software facilitates the study of electrical therapies, aiding in clinical applications.