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Updated: Jun 18, 2026
A Piglet Model of Neonatal Hypoxic-Ischemic Encephalopathy
Published on: May 16, 2015
Hypoxic-ischemic brain injury in neonatal piglets with different histological outcomes: An amplitude-integrated EEG
Dandan Zhang1, Manan Hathi, Zeng-Jin Yang
1Department of Biomedical Engineering, Tsinghua University, Beijing, 100084 China. zhangdd05@gmail.com
Abstract:
To test the reliability of amplitude-integrated electroencephalogram (aEEG) in cerebral hypoxic ischemia (HI), 12 neonatal piglets subjected to different levels of HI are divided into three groups based on the histological outcomes obtained 4 days after experiment. Results show that concomitant with the increased severity of brain injury, the upper and lower margins of aEEG decrease significantly (p < 0.05) during early recovery period after HI (about 2 hours post-resuscitation). We conclude that aEEG method reliably reflects hypoxic-ischemic cerebral injury and constitutes a valuable monitoring tool in neonatal intensive care unit (NICU).
