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Updated: Jun 18, 2026

Measurement of Scattering Nonlinearities from a Single Plasmonic Nanoparticle

Measurement of Scattering Nonlinearities from a Single Plasmonic Nanoparticle

Published on: January 3, 2016

Elastic nonlinearity imaging.

Timothy J Hall¹, Assad A Oberait, Paul E Barbone

¹Medical Physics Department, University of Wisconsin, Madison, Wisconsin 53706, USA.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

|December 8, 2009

Summary

This summary is machine-generated.

This study enhances breast cancer diagnosis using 3D/4D ultrasound elastography, incorporating tissue nonlinearity and modulus imaging. These advanced techniques improve diagnostic specificity by differentiating tumor types based on elastic properties.

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Area of Science:

Medical Imaging
Biophysics
Oncology

Background:

Ultrasound elastography improves breast cancer diagnosis compared to B-mode imaging alone.
Tissue motion out-of-plane and contrast changes with deformation complicate elasticity imaging.

Purpose of the Study:

To extend ultrasound elastography methods to 3D/4D imaging using 2D arrays.
To investigate tissue stress-strain nonlinearity and its impact on tumor characterization.
To develop absolute elastic parameter (modulus) imaging for in vivo breast tissues.

Main Methods:

Development of 3D/4D elastography techniques to track out-of-plane motion.
Investigation of tissue stress-strain nonlinearity under large deformations (>20%).
Implementation of piecewise linear and nonlinear modulus reconstructions based on 2D displacement estimates.

Main Results:

Modulus reconstructions approximate absolute elastic contrast, unlike strain images.
Nonlinear reconstructions provide images of shear modulus and a nonlinearity parameter.
Clinical data suggest invasive ductal carcinoma exhibits greater nonlinearity than fibroadenoma.

Conclusions:

3D/4D elastography and modulus imaging offer enhanced diagnostic capabilities for breast tumors.
Tissue stress-strain nonlinearity may improve diagnostic specificity for differentiating tumor types.
Further extension to 3D imaging is ongoing.