Polyimide-based multi-channel arrayed electrode for measuring EEG signal on the skull of mouse

Area of Science:

• Neuroscience
• Biomedical Engineering
• Materials Science

Background:

• Electroencephalography (EEG) is crucial for studying brain activity.
• Developing high-density, implantable electrodes is essential for advanced neural recordings.
• Current electrode technologies face challenges in signal quality and long-term stability.

Purpose of the Study:

• To develop and evaluate a novel 40-channel microelectrode array for in vivo EEG measurements in mice.
• To assess the performance of platinum-plated electrodes for enhanced signal acquisition and durability.
• To investigate the feasibility of using the electrode array for monitoring brain state changes.

Main Methods:

• Fabrication of a 40-channel electrode array on a polyimide substrate.
• Platinum electroplating of electrode recording sites to improve impedance and adhesion.
• In vivo implantation on the skull of F1 mice for EEG signal recording.
• Analysis of EEG signal spectra following urethane administration.

Main Results:

• Successfully developed and tested a 40-channel polyimide-based electrode array.
• Platinum plating enhanced electrode contact impedance and adhesive strength.
• The electrode array proved suitable for measuring EEG signals from multiple cranial locations.
• EEG signal spectra exhibited changes upon urethane administration, indicating functional sensitivity.

Conclusions:

• The developed 40-channel microelectrode array is a viable tool for high-density in vivo EEG recordings in mice.
• Platinum-plated electrodes offer improved performance characteristics for neural interface applications.
• This technology facilitates the study of brain activity and neurological changes in animal models.