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Novel Photoacoustic Microscopy and Optical Coherence Tomography Dual-modality Chorioretinal Imaging in Living Rabbit Eyes
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Light-controlled retinal stimulation on rabbit using CMOS-based flexible multi-chip stimulator.

T Tokuda1, Y Takeuchi, T Noda

  • 1Nara Institute Science and Technology, Takayama-cho 8916-5, Ikoma, Nara, 630-0192, Japan. tokuda@ms.naist.jp

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
|December 8, 2009
PubMed
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This study introduces a retinal prosthesis with integrated light-sensing capabilities for image-based stimulation. This innovation enables on-site light-controlled retinal stimulation, simplifying the prosthesis concept.

Area of Science:

  • Biomedical Engineering
  • Neuroscience
  • Ophthalmology

Background:

  • Retinal prostheses aim to restore vision by stimulating remaining retinal neurons.
  • Current retinal prostheses often lack sophisticated on-site visual processing capabilities.
  • Integrating light-sensing with stimulation offers a pathway towards more intuitive visual restoration.

Purpose of the Study:

  • To develop and validate a multi-chip stimulator with integrated light-sensing for image-based patterned retinal stimulation.
  • To demonstrate the feasibility of on-site light-controlled decision-making for retinal stimulation.
  • To present a simplified concept for a retinal prosthesis incorporating on-site imaging.

Main Methods:

  • Implementation of light-sensing circuitry on a CMOS-based multi-chip stimulator.

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  • Attachment of light-sensing circuitry to individual stimulation electrodes.
  • Verification of light-controlled decision-making based on localized light intensity measurements.
  • In vivo demonstration of light-controlled retinal stimulation in rabbit models.

    • Main Results:

    • The developed multi-chip stimulator successfully integrated light-sensing functionality.
    • Image-based patterned stimulation was achieved using the light-sensing circuitry.
    • Light-controlled decision-making based on measured light intensity was experimentally verified.
    • Successful in vivo retinal stimulation with light-controlled decision was demonstrated in rabbits.

    Conclusions:

    • The integration of light-sensing with stimulation electrodes is feasible for retinal prostheses.
    • On-site imaging and light-controlled decision-making can enhance retinal prosthesis functionality.
    • This work provides a simplified yet effective demonstration of a retinal prosthesis concept with integrated visual feedback.