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Related Experiment Video

Updated: Jun 18, 2026

Interfacing Microfluidics with Microelectrode Arrays for Studying Neuronal Communication and Axonal Signal Propagation

Interfacing Microfluidics with Microelectrode Arrays for Studying Neuronal Communication and Axonal Signal Propagation

Published on: December 8, 2018

A cell-electrode interface noise model for high-density microelectrode arrays.

Neil Joye¹, Alexandre Schmid, Yusuf Leblebici

¹Microelectronic Systems Laboratroy, Swiss Federal Institute of Technology (EPFL), 1015 Lausanne, Switzerland. neil.joye@epfl.ch

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

|December 8, 2009

Summary

This summary is machine-generated.

A new noise model for cell-electrode interfaces helps simulate CMOS-based MEAs. Electrode noise, especially from Pt black, can dominate, but shows reduced output noise for small electrodes.

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Area of Science:

Biomedical Engineering
Electrical Engineering
Neuroscience

Background:

Novel CMOS-based Microelectrode Arrays (MEAs) require accurate electrical characteristic modeling.
Understanding cell-electrode interface noise is crucial for high-fidelity biosignal recording.

Purpose of the Study:

To develop a cell-electrode interface noise model for co-simulation of MEA electrical characteristics and electronics.
To investigate electrode noise sources, specifically for Platinum (Pt) and Platinum black (Pt black) electrodes.

Main Methods:

Development of a dedicated noise model for cell-electrode interfaces.
Investigation of electrode noise for Pt and Pt black electrodes.
Analysis of noise spectral density with and without neural cells present.

Main Results:

Electrode noise can be the dominant noise source in the complete MEA system.
Pt black electrodes exhibit up to 5 microV(rms) lower output noise for small electrode sizes.
Cell presence increases cell-electrode interface noise spectral density by 10-20 dB at 1 kHz, dependent on cell adhesion.

Conclusions:

The developed noise model enables co-simulation of MEA electrical properties and integrated electronics.
Pt black electrodes offer noise reduction benefits, particularly for micro-scale applications.
Neural cell adhesion significantly impacts the noise characteristics of the cell-electrode interface.