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Updated: Jun 18, 2026

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
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Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

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3-D microfabricated electrodes for targeted deep brain stimulation.

Noppasit Laotaveerungrueng1, Chia-Hua Lin, Grant McCallum

  • 1Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH 44106, USA. nxl30@case.edu

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
|December 8, 2009
PubMed
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This study introduces a novel 4-sided deep brain stimulation electrode for precise, directional electrical current delivery. This innovation enhances targeted stimulation capabilities in neuromodulation applications.

Area of Science:

  • Biomedical Engineering
  • Neuroscience
  • Electrical Engineering

Background:

  • Deep brain stimulation (DBS) is a therapeutic approach for neurological disorders.
  • Current DBS electrodes offer limited control over current field directionality.
  • Need for advanced electrode designs to improve stimulation specificity and efficacy.

Purpose of the Study:

  • To present a novel 4-sided, 16-channel deep brain stimulation electrode.
  • To enable circumferential steering of the electrical current field.
  • To validate the design through finite element analysis and in vitro testing.

Main Methods:

  • Fabrication using micromachining and microfabrication techniques.
  • Mechanical assembly of electrode components.

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Last Updated: Jun 18, 2026

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
14:14

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

Microelectrode Guided Implantation of Electrodes into the Subthalamic Nucleus of Rats for Long-term Deep Brain Stimulation
10:52

Microelectrode Guided Implantation of Electrodes into the Subthalamic Nucleus of Rats for Long-term Deep Brain Stimulation

Published on: October 2, 2015

Deep Brain Stimulation with Simultaneous fMRI in Rodents
11:09

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Published on: February 15, 2014

  • Finite element analysis (FEA) for modeling current distribution.
  • In vitro testing to validate targeted stimulation.

    • Main Results:

    • The 3-dimensional electrode allows for directional current field steering.
    • Simulation and experimental results for targeted stimulation show close agreement.
    • Symmetric bipolar configuration achieved a 3.6x higher electric potential on the activated side compared to adjacent sides, and 9x higher than the opposite side within a 3 mm radius.

    Conclusions:

    • The novel 4-sided DBS electrode design facilitates precise, directional current steering.
    • The validated design concept shows potential for enhanced targeted stimulation.
    • This technology could improve the efficacy and reduce side effects of DBS therapy.