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Pulse rhythm01:30

Pulse rhythm

Pulse rhythm refers to the pattern of pulsations within specific intervals, offering valuable insights into the regularity or irregularity of the heart's beats as observed through the pattern of pulsation within specific intervals. A regular pulse exhibits a consistent heart rate with uniform waveforms and pulsation force, variations of which can be classified as normal, weak, or bounding.
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac muscle...

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Related Experiment Video

Updated: Jun 18, 2026

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia
09:36

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia

Published on: December 22, 2023

Monitoring intramyocardial reentry using alternating transillumination.

Bogdan G Mitrea1, Marcel Wellner, Arkady M Pertsov

  • 1State University of New York, Upstate Medical University, Syracuse, NY 13210, USA. mitreab@upstate.edu

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
|December 8, 2009
PubMed
Summary

A new imaging technique, alternating transillumination (AT), allows visualization of electrical activity in the heart. This method helps understand the mechanisms behind life-threatening cardiac arrhythmias like polymorphic ventricular tachycardia.

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Related Experiment Videos

Last Updated: Jun 18, 2026

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Published on: May 12, 2019

Area of Science:

  • Cardiovascular Physiology
  • Biomedical Imaging
  • Cardiac Electrophysiology

Background:

  • Intramyocardial reentry is a key factor in fatal cardiac arrhythmias, including polymorphic ventricular tachycardia and ventricular fibrillation.
  • Understanding the mechanisms triggering and controlling reentry dynamics is crucial but hindered by limitations in 3D imaging of cardiac electrical activity.
  • Existing tools are inadequate for visualizing electrical excitation and reentry within thick ventricular walls.

Purpose of the Study:

  • To introduce and validate a novel experimental technique, alternating transillumination (AT), for 3D imaging of cardiac electrical activity.
  • To address the gap in tools for studying intramyocardial reentry dynamics in thick cardiac tissue.
  • To investigate the dynamics of reentry during experimentally induced polymorphic ventricular tachycardia.

Main Methods:

  • Development and application of the alternating transillumination (AT) technique.
  • Utilization of a near-infrared fluorescent voltage-sensitive dye, DI-4-ANBDQBS.
  • In vivo study of shock-induced polymorphic ventricular tachycardia in pig myocardium.

Main Results:

  • The AT technique provides unprecedented 3D visualization of electrical excitation and reentry in thick myocardial tissue.
  • Dynamics of reentry during polymorphic ventricular tachycardia were successfully studied using AT.
  • The study demonstrated the feasibility of AT for investigating complex cardiac electrical phenomena.

Conclusions:

  • Alternating transillumination (AT) is a powerful new tool for studying cardiac electrical activity and arrhythmias.
  • This technique facilitates a deeper understanding of intramyocardial reentry mechanisms.
  • AT has the potential to advance research into the causes and potential treatments of life-threatening cardiac arrhythmias.