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Integrated electronics for peripheral nerve recording and signal processing.

Kanokwan Limnuson1, Dustin J Tyler, Pedram Mohseni

  • 1Electrical Engineering and Computer Science Department, Case Western Reserve University, Cleveland, OH, USA.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
|December 8, 2009
PubMed
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This study presents an integrated circuit for recording phrenic nerve activity to control a laryngeal pacemaker. The system aims to reanimate paralyzed muscles by electrically stimulating them in sync with breathing.

Area of Science:

  • Biomedical Engineering
  • Neuroprosthetics
  • Integrated Circuit Design

Background:

  • Peripheral nerve recording is crucial for advanced neuroprosthetic applications.
  • The phrenic nerve serves as a key indicator of respiratory function.
  • Restoring muscle function often requires precise electrical stimulation synchronized with physiological signals.

Purpose of the Study:

  • To develop and implement an integrated circuit for peripheral nerve recording and signal processing.
  • To create a system capable of recording neural activity from the phrenic nerve.
  • To generate a stimulus trigger signal for a laryngeal pacemaker to achieve muscle reanimation.

Main Methods:

  • Fabrication of a 2.2 x 2.2-mm(2) integrated circuit using the AMI 1.5 microm 2P/2M n-well CMOS process.

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  • Design and simulation of the electronic system for neural recording and signal conditioning.
  • Benchtop experiments to validate system performance and measurement data.

    • Main Results:

    • Successful implementation of an integrated circuit for peripheral nerve recording.
    • Demonstration of neural activity conditioning from the phrenic nerve.
    • Generation of a stimulus trigger signal for a laryngeal pacemaker device.

    Conclusions:

    • The developed integrated circuit provides a low-power solution for respiratory-gated muscle stimulation.
    • This system shows potential for reanimating paralyzed muscles through electrical stimulation.
    • The presented design facilitates advancements in neuroprosthetics and assistive device technology.