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Updated: Jun 18, 2026

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
Published on: December 18, 2016
Analysis of epileptogenic network properties during ictal activity
Christopher Wilke1, Gregory A Worrell, Bin He
1Department of Biomedical Engineering at the University of Minnesota, Minneapolis, MN 55455, USA. wilk0242@umn.edu
None:
In the present study, we utilize methods from graph theory to analyze epileptogenic network properties during periods of ictal activity. Using these methods, we analyzed the DTF-based causal information flow in nine seizures recorded from two patients undergoing presurgical monitoring for the treatment of medically intractable epilepsy. From the results, we observed a high degree of correlation between the regions with a high amount of information outflow (termed the outdegree) and the cortical areas identified clinically as the generators of the ictal activity. We furthermore observe a frequency-dependent correlation between the co-localization of these "activated regions" and the clinical foci. These findings suggest that application of network analysis tools to ictal activity could provide clinically useful information concerning these epileptogenic networks.
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