Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 18, 2026

Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform
10:42

Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform

Published on: June 15, 2021

Microfluidic cardiac circulation model (microCCM) for functional cardiomyocyte studies.

Mai-Dung Nguyen1, Guruprasad Giridharan, Sumanth D Prabhu

  • 1Department of Bioengineering, University of Louisville, Louisville, KY 40208, USA.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
|December 8, 2009
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Extracellular Vesicles Mediate Activation and Trafficking of Splenic Immune Cells to the Heart Post-Myocardial Infarction.

bioRxiv : the preprint server for biology·2026
Same author

Roadmap to Revitalizing Academic Cardiovascular Medicine: A Perspective From the Association of Professors of Cardiology (APC) Emerging Leaders Group.

Journal of the American College of Cardiology·2026
Same author

Transmitophagy in the heart: An overview of molecular mechanisms and implications for pathophysiology.

Acta pharmaceutica Sinica. B·2026
Same author

Mitochondrial DNA is an important signaling molecule in cardiovascular aging and pathophysiology.

American journal of physiology. Heart and circulatory physiology·2026
Same author

Effect of Pulse Frequency on Shear-Induced Extension of Von Willebrand Factor in Continuous-Flow Ventricular Assist Device (CF-VAD).

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2025
Same author

S100A8/9-NLRP3-mediated chronic unresolved inflammation drives cardiac pathologies following invasive pneumococcal disease.

Experimental & molecular medicine·2025

Researchers developed a novel Microfluidic Cardiac Circulation Model (microCCM) to study how heart cells respond to mechanical stress. This innovative model aids in understanding cardiovascular disease mechanisms and developing new treatments.

Area of Science:

  • Cardiovascular Science
  • Biomedical Engineering
  • Cellular Mechanobiology

Background:

  • Cardiomyocytes respond to mechanical stress, crucial for heart development and function.
  • Disrupted stress-sensing in cardiomyocytes leads to cardiac dysfunction, remodeling, and heart failure.
  • Current in-vitro models lack the physiological relevance needed to study cardiovascular disease (CVD) pathogenesis.

Purpose of the Study:

  • To develop a physiologically relevant in-vitro model for studying CVD.
  • To investigate signaling mechanisms underlying cardiac dysfunction and heart failure.

Main Methods:

  • Development of a Microfluidic Cardiac Circulation Model (microCCM).
  • Integration of mechanically loaded cardiomyocytes with fluid flow and a circulation network.

More Related Videos

Fabrication of 3D Cardiac Microtissue Arrays using Human iPSC-Derived Cardiomyocytes, Cardiac Fibroblasts, and Endothelial Cells
10:37

Fabrication of 3D Cardiac Microtissue Arrays using Human iPSC-Derived Cardiomyocytes, Cardiac Fibroblasts, and Endothelial Cells

Published on: March 14, 2021

Related Experiment Videos

Last Updated: Jun 18, 2026

Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform
10:42

Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform

Published on: June 15, 2021

Fabrication of 3D Cardiac Microtissue Arrays using Human iPSC-Derived Cardiomyocytes, Cardiac Fibroblasts, and Endothelial Cells
10:37

Fabrication of 3D Cardiac Microtissue Arrays using Human iPSC-Derived Cardiomyocytes, Cardiac Fibroblasts, and Endothelial Cells

Published on: March 14, 2021

  • Utilizing the microCCM to simulate hemodynamic loading and unloading conditions.

    • Main Results:

    • The microCCM successfully integrates mechanical loading and fluid flow with cardiomyocytes.
    • The model provides a platform to study cardiomyocyte responses to mechanical stress.
    • Enables investigation of signaling pathways in cardiovascular disease pathogenesis.

    Conclusions:

    • The microCCM represents a significant advancement in creating physiologically relevant in-vitro models for cardiac research.
    • This model facilitates a deeper understanding of the mechanisms driving cardiovascular diseases.
    • Offers potential for improved diagnostics and therapeutic strategies for heart conditions.