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A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
Published on: June 2, 2022
Longitudinal relationships among coronary artery calcification, serum phosphorus, and kidney function
Katherine R Tuttle1, Robert A Short
1Providence Medical Research Center, Spokane, WA 99224, USA. katherine.tuttle@providence.org
Clinical Journal of the American Society of Nephrology : CJASN
|December 8, 2009
Summary
Coronary artery calcification (CAC) progresses over time in adults. Higher serum phosphorus and reduced kidney function independently predict CAC development and severity.
Area of Science:
- Cardiovascular Disease Research
- Nephrology
- Biomarkers of Atherosclerosis
Background:
- Coronary artery calcification (CAC) is prevalent in advanced chronic kidney disease (CKD).
- The onset and progression of CAC in relation to kidney function are not well understood.
Purpose of the Study:
- To investigate the longitudinal associations between coronary artery calcification (CAC), kidney function, and cardiovascular disease (CVD) risk factors.
Main Methods:
- Prospective cohort analysis from the Spokane Heart Study.
- Longitudinal assessment of CAC using electron-beam computed tomography (EBCT) every 2 years.
- Evaluation of traditional and putative CVD risk factors, including estimated glomerular filtration rate (eGFR) and serum phosphorus levels.
Main Results:
- Coronary artery calcification (CAC) was present in 28% at baseline and new-onset CAC developed in 33% over 6 years.
- Increased CAC severity was observed in individuals with pre-existing CAC.
- Multivariate analysis identified higher baseline CAC scores, elevated serum phosphorus, lower eGFR, and traditional CVD risk factors as independent predictors of CAC over time.
Conclusions:
- Coronary artery calcification (CAC) incidence and severity increase over time.
- Elevated serum phosphorus levels and reduced kidney function are independent predictors of CAC development and progression.
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