Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunotactoid glomerulopathy.

S M Korbet1, M M Schwartz, E J Lewis

  • 1Department of Medicine, Rush Presbyterian St. Lukes Medical Center, Chicago, IL.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|March 1, 1991
PubMed
Summary

Immunotactoid glomerulopathy is an increasingly recognized kidney disease. This condition involves unique glomerular deposits and often leads to significant renal dysfunction and end-stage renal disease.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Zoonotic protozoa in the marine environment: a threat to aquatic mammals and public health.

Veterinary parasitology·2014
Same author

Prolonged hypothermia.

Project report. USAF School of Aviation Medicine·2014
Same author

Chromosome location of two isozyme loci in Lolium perenne using primary trisomics.

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2013
Same author

Chromosome pairing in tetraploid hybrids between Lolium perenne and L. multiflorum.

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2013
Same author

Genetic segregation in relation to chromosome pairing in tetraploid hybrids between Lolium perenne and L. multiflorum.

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2013
Same author

Proteinuria in membranous lupus nephritis: the pathology is in the podocyte.

Lupus·2013

Area of Science:

  • Nephrology
  • Pathology
  • Immunology

Background:

  • Immunotactoid glomerulopathy (ITG) is increasingly recognized.
  • Histologically, ITG features organized ultrastructural deposits of immunoglobulin and complement, distinct from amyloid.
  • ITG is differentiated from other glomerular deposit diseases like cryoglobulinemia, amyloidosis, and lupus nephritis.

Purpose of the Study:

  • To describe the clinical and histopathological characteristics of immunotactoid glomerulopathy.
  • To highlight the diagnostic criteria and differential diagnoses for ITG.
  • To review the current understanding of ITG's clinical course, treatment outcomes, and prognosis.

Main Methods:

  • Histological examination of kidney biopsies.
  • Immunofluorescence and electron microscopy to characterize glomerular deposits.
  • Clinical data review including patient presentation, laboratory findings, and disease progression.

Main Results:

  • ITG presents with proteinuria (≥60% in nephrotic range), hypertension, hematuria, and renal insufficiency in over half of patients.
  • Over 40% of reported patients progress to end-stage renal disease.
  • Limited treatment efficacy with prednisone or immunosuppression; renal transplant outcomes are variable with recurrence risk.

Conclusions:

  • Immunotactoid glomerulopathy is a distinct primary glomerulopathy characterized by organized glomerular deposits.
  • The disease frequently leads to progressive renal failure, with limited treatment options.
  • Further research into the pathogenesis of ITG is warranted.

Related Experiment Videos