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Prolonged survival with a remnant kidney
M H Foster1, G R Sant, J F Donohoe
1Renal Service, New England Medical Center Hospital, Dublin, Ireland.
Summary
Humans can live over 30 years with a remnant kidney after surgery. This study shows stable kidney function is possible, even after significant renal mass ablation, challenging previous assumptions about progressive renal failure.
Area of Science:
- Nephrology
- Urology
- Transplant Surgery
Background:
- Surgical removal of significant renal mass can lead to focal sclerosis and renal failure in animal models.
- Existing human data on remnant kidneys are limited, primarily from unilateral renal agenesis, uninephrectomy, or isolated case reports.
- Concerns exist regarding intraglomerular hypertension and hyperfiltration as mechanisms for injury in remnant kidneys.