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Identification of two common variants contributing to serum apolipoprotein B levels in Mexicans

Daphna Weissglas-Volkov1, Christopher L Plaisier, Adriana Huertas-Vazquez

  • 1Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, Calif 90095-7088, USA.

Arteriosclerosis, Thrombosis, and Vascular Biology
|December 8, 2009
PubMed
Abstract

Insights

Researchers identified two novel genetic variants, rs1349411 and rs1424032, associated with serum apolipoprotein B (apoB) levels in the Mexican population, contributing to understanding dyslipidemia risk.

Area of Science:

  • Genetics
  • Cardiovascular Disease Research
  • Population Health

Background:

  • The Mexican population exhibits a high prevalence of dyslipidemias and premature coronary artery disease.
  • Genetic factors contributing to this susceptibility in Mexicans remain under-investigated.

Purpose of the Study:

  • To identify genetic factors associated with high serum apolipoprotein B (apoB) levels in the Mexican population.
  • To investigate genetic predispositions to dyslipidemias and premature coronary artery disease in Mexicans.

Main Methods:

  • A two-step strategy was employed, screening 5721 single-nucleotide polymorphisms (SNPs) for linkage with apoB levels in Mexican families with familial combined hyperlipidemia.
  • 130 SNPs in linkage regions were analyzed for association with apoB, followed by replication in Mexican hyperlipidemic case-control samples.

Main Results:

  • Two SNPs, rs1424032 (P=6.07x10(-6)) and rs1349411 (P=2.72x10(-4)), showed significant association with apoB levels, surpassing the stringent significance threshold.
  • Replication in case-control samples confirmed the association of the same risk alleles with elevated apoB levels.
  • rs1349411 is located near APOB messenger RNA editing enzyme (APOBEC1), while rs1424032 is in a conserved regulatory noncoding region.

Conclusions:

  • Two novel variants, rs1349411 and rs1424032, were identified as significantly associated with serum apoB levels in the Mexican population.
  • These findings contribute to understanding the genetic basis of dyslipidemia and coronary artery disease susceptibility in Mexicans.

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