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Updated: Jun 18, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

Epidemic dynamics revealed in dengue evolution.

S N Bennett¹, A J Drummond, D D Kapan

¹Department of Tropical Medicine, Medical Microbiology and Pharmacology, Asia-Pacific Institute of Tropical Medicine and Infectious Diseases, J.A. Burns School of Medicine, University of Hawaii at Manoa, Hawaii, USA. sbennett@hawaii.edu

Molecular Biology and Evolution

|December 8, 2009

Summary

This summary is machine-generated.

Dengue virus 4 (DENV-4) epidemics in Puerto Rico correlate with viral genetic diversity fluctuations. Population bottlenecks during interepidemic periods impact DENV evolution, informing disease surveillance strategies.

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Area of Science:

* Virology and Epidemiology: Investigating the evolutionary dynamics of mosquito-borne viral diseases.
* Molecular Evolution: Analyzing viral genetic diversity to understand transmission patterns.

Background:

* Dengue fever is a significant tropical disease caused by mosquito-borne dengue viruses (DENV), with Puerto Rico experiencing severe epidemics.
* DENV-4 transmission in Puerto Rico has shown periodic epidemic cycles linked to viral serotype introductions.

Purpose of the Study:

* To investigate the phylodynamics of DENV-4 in Puerto Rico from 1981 to 1998.
* To correlate viral evolutionary changes with observed epidemic patterns using genetic and epidemiological data.

Main Methods:

* Phylodynamic analysis of DENV-4 sequences collected between 1981 and 1998.
* Bayesian Markov Chain Monte Carlo methods to estimate effective population size from genetic diversity.
* Integration of viral sequence data with confirmed dengue case counts.

Main Results:

* Cyclic dengue epidemics strongly correlate with fluctuations in DENV-4 effective population size estimated from genetic data.
* Interepidemic periods show reduced genetic diversity, indicative of population bottlenecks impacting viral evolution.
* Increased effective population size precedes reported case counts, suggesting potential surveillance bias.

Conclusions:

* Viral genetic diversity provides insights into dengue transmission dynamics and epidemic cycles.
* Population bottlenecks play a crucial role in DENV evolutionary trajectories.
* Integrating genetic and epidemiological data enhances understanding of infectious disease spread and surveillance.