Related Experiment Video
Updated: Jun 18, 2026
06:18
An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
Endothelial progenitor cell senescence--is there a role for estrogen?
Toshio Imanishi1, Hiroto Tsujioka, Takashi Akasaka
1Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan. t-imani@wakayama-med.ac.jp
Therapeutic Advances in Cardiovascular Disease
|December 8, 2009
Summary
Aging endothelial progenitor cells (EPCs) limit tissue repair due to reactive oxygen species (ROS). Estrogen reduces EPC senescence by boosting telomerase activity, improving cell function for potential therapies.
Area of Science:
- Cardiovascular Biology
- Cellular Aging
- Regenerative Medicine
Background:
- Endothelial progenitor cells (EPCs) are crucial for ischemic tissue repair.
- Cellular senescence, driven by reactive oxygen species (ROS), impairs EPC function and neovascularization.
- Estrogens show promise in accelerating endothelial recovery post-vascular injury.
Purpose of the Study:
- To review the current understanding of EPC senescence.
- To elucidate the role of estrogen in preventing EPC senescence.
- To explore the therapeutic potential of estrogen in cell-based therapies.
Main Methods:
- Literature review of studies on EPC senescence and estrogen effects.
- Analysis of mechanisms linking ROS to EPC aging.
- Examination of estrogen's impact on telomerase activity and EPC function.
Main Results:
- EPC senescence is a key barrier to effective ischemic tissue repair.
- Estrogen mitigates EPC senescence by enhancing telomerase activity.
- Inhibition of EPC senescence by estrogen improves their functional capacity in vitro.
Conclusions:
- Estrogen plays a protective role against EPC senescence.
- Targeting EPC senescence with estrogen may enhance cell therapy outcomes for vascular repair.
- Further research into estrogen-mediated pathways could yield novel therapeutic strategies.
More Related Videos
Related Concept Videos
01:24Regulation of Angiogenesis and Blood Supply
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
01:22Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
01:19Multipotency of Hematopoietic Stem Cells
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
02:15Replicative Cell Senescence
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
01:28Menopause
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
01:26Stem Cell Niche
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...