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Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform

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Published on: November 7, 2013

Reducing workplace cytotoxic surface contamination using a closed-system drug transfer device.

Jim Siderov¹, Sue Kirsa, Robert McLauchlan

¹Pharmacy Department, Austin Health, Heidelberg, Victoria, Australia. jim.siderov@austin.org.au

Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners

|December 8, 2009

Summary

A closed system drug transfer device (PhaSeal) significantly reduced cytotoxic surface contamination in hospital preparation areas. This intervention further minimized exposure risks, even to undetectable levels, enhancing workplace safety for healthcare staff handling hazardous drugs.

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Area of Science:

Occupational Health and Safety
Pharmaceutical Sciences
Environmental Health

Background:

Healthcare staff face risks from antineoplastic agent exposure despite safety protocols.
Cytotoxic drug safety cabinets (CDSC) alone are insufficient for complete protection.
Closed system drug transfer devices (CSTDDs) like PhaSeal offer a superior method for preventing contamination.

Purpose of the Study:

To evaluate the effectiveness of the PhaSeal CSTDD in reducing cytotoxic surface contamination.
To assess the impact of CSTDDs in Australian hospital settings.
To quantify reductions in hazardous drug contamination in preparation areas.

Main Methods:

A pre- and post-intervention study design was employed.
Surface wipe sampling was conducted at baseline, 5, and 12 months post-intervention.
Cyclophosphamide served as a surrogate marker for cytotoxic drug contamination.

Main Results:

Total surface contamination decreased by 24% after 5 months and 68% after 12 months.
Contamination was reduced in 59% of sites after 5 months and 75% after 12 months.
Undetectable levels of contamination were achieved in some sites.

Conclusions:

The PhaSeal CSTDD significantly reduces cytotoxic surface contamination.
Using PhaSeal within a CDSC enhances safety by further minimizing contamination.
This technology is effective in reducing occupational exposure risks in cytotoxic drug preparation areas.