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Related Concept Videos

What is the Cell Cycle?00:56

What is the Cell Cycle?

The cell cycle refers to the sequence of events occurring throughout a typical cell’s life. In eukaryotic cells, the somatic cell cycle has two stages: the interphase and the mitotic phase. During interphase, the cell grows, performs its basic metabolic functions, copies its DNA, and prepares for mitotic cell division. Then, during mitosis and cytokinesis, the cell divides its nuclear and cytoplasmic materials, respectively. This generates two daughter cells that are identical to the original...
What is the Cell Cycle?01:04

What is the Cell Cycle?

The cell cycle refers to the sequence of events occurring throughout a typical cell’s life. In eukaryotic cells, the somatic cell cycle has two stages: interphase and the mitotic phase. During interphase, the cell grows, performs its basic metabolic functions, copies its DNA, and prepares for mitotic cell division. Then, during mitosis and cytokinesis, the cell divides its nuclear and cytoplasmic materials, respectively. This generates two daughter cells that are identical to the original...
The Cell Cycle Control System01:28

The Cell Cycle Control System

The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
Molecular Factors Affecting Cell Division01:27

Molecular Factors Affecting Cell Division

Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
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Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics
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Cell-cycle times and the tumour control probability.

Adrian Maler1, Frithjof Lutscher

  • 1Department of Mathematics and Statistics, University of Ottawa, 585 King Edward Avenue, Ottawa, Ontario, Canada K1N 6N5.

Mathematical Medicine and Biology : a Journal of the IMA
|December 8, 2009
PubMed
Summary

Realistic cell cycle models improve tumor control probability (TCP) predictions. More precise cell cycle distributions allow for lower treatment doses in constant therapies but require higher doses for fractionated treatments.

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Area of Science:

  • Mathematical biology
  • Radiation oncology
  • Cancer research

Background:

  • Current mechanistic dynamic cell population models for tumor control probability (TCP) use simplified cell cycle representations.
  • These simplifications, such as exponential distributions or two-compartment models, do not accurately reflect realistic, narrowly peaked cell-cycle time distributions.

Purpose of the Study:

  • To investigate the impact of realistic cell-cycle time distributions on TCP predictions.
  • To analyze the influence of compartmental independence in the 'active-quiescent' model.
  • To develop and apply a deterministic age-structured model and a branching process for more accurate TCP calculations.

Main Methods:

  • Revisiting the 'active-quiescent' model and assessing the impact of compartmental independence.
  • Formulating a deterministic age-structured model.
  • Developing a corresponding branching process model.
  • Comparing TCP predictions using simplified versus realistic cell-cycle time distributions under constant and fractionated treatment protocols.

Main Results:

  • Realistic cell-cycle time distributions lead to lower required treatment intensities for achieving the same TCP under constant time treatments compared to simplified models.
  • For fractionated treatments, the inverse is observed: more intense treatment is required under realistic cell-cycle time distributions to achieve the same TCP.

Conclusions:

  • Incorporating realistic cell-cycle time distributions significantly alters TCP predictions, especially in fractionated radiotherapy.
  • The findings suggest that current simplified models may overestimate or underestimate treatment efficacy depending on the delivery protocol.
  • More accurate cell cycle modeling is crucial for optimizing radiation therapy strategies and improving tumor control outcomes.