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Heart Failure II: Pathophysiology

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Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery
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Alterations in left ventricular untwisting with ageing.

Bas M van Dalen1, Osama I I Soliman, Floris Kauer

  • 1Department of Cardiology, The Thoraxcenter, Erasmus University Medical Center, The Netherlands.

Circulation Journal : Official Journal of the Japanese Circulation Society
|December 8, 2009
PubMed
Summary

Left ventricular (LV) untwisting slows with age, with delayed untwisting potentially explaining diastolic dysfunction in older adults. This study investigated age-related changes in LV untwisting dynamics.

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Area of Science:

  • Cardiology
  • Gerontology
  • Biomedical Engineering

Background:

  • Age-associated changes in left ventricular (LV) diastolic function are not fully understood.
  • Investigating LV untwisting alterations with aging is crucial for insight into diastolic function.

Purpose of the Study:

  • To investigate age-related changes in left ventricular (LV) untwisting.
  • To determine how LV untwisting dynamics are affected by aging.

Main Methods:

  • 75 healthy volunteers were divided into three age groups (16-35, 36-55, 56-75 years).
  • Speckle-tracking echocardiography assessed LV untwisting parameters, including untwisting velocity and untwisting rate.
  • Key metrics analyzed were LV untwisting at specific diastolic percentages, peak diastolic untwisting velocity, time-to-peak, and untwisting rate.

Main Results:

  • LV untwisting decreased at 5%, 10%, 15%, and 50% of diastole with increasing age.
  • Normalized peak diastolic untwisting velocity and untwisting rate decreased significantly with advancing age (P<0.01).
  • Time-to-peak diastolic untwisting velocity increased with age (P<0.01), indicating delayed untwisting.

Conclusions:

  • Impaired relative peak diastolic untwisting velocity and untwisting rate contribute to delayed LV untwisting in the elderly.
  • These age-related changes in LV untwisting may elucidate the mechanisms of diastolic dysfunction in older populations.
  • Understanding these alterations is vital for managing age-related cardiovascular changes.