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Updated: Jun 18, 2026

Robotic Duodenal Sleeve Resection for Gastrointestinal Stromal Tumor with Rare Exon 8 KIT Mutation Following Neoadjuvant Imatinib
Published on: April 3, 2026
[A case of rectal GIST treated with imatinib mesylate neoadjuvant therapy to preserve the anus]
Satoru Sekoguchi1, Yusuke Okuyama, Yasuyuki Enoki
1Department of Gastroenterology, Kyoto First Red Cross Hospital, Japan. satoru-sekoguchi@kyoto1-jrc.org
Abstract:
A 64-year-old man was admitted to our hospital with anal pain on evacuation. MRI revealed a large rectal submucosal tumor, more than 6 cm in diameter. Fine needle histological diagnosis indicated GIST with moderate risk. The patient was treated with imatinib mesylate in order to preserve the anus. The anal pain and tumor size decreased. Trans-anal local excision was performed. This case suggests that imatinib mesylate can make it possible to treat large rectal GIST cases by preserving anus, if neoadjuvant chemotherapy can be effective.
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