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Related Concept Videos

Skin Diseases and Disorders01:23

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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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Acrodermatitis due to nutritional deficiency.

Kathryn A Gehrig1, James G H Dinulos

  • 1Section of Dermatology, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA.

Current Opinion in Pediatrics
|December 8, 2009
PubMed
Summary
This summary is machine-generated.

Skin manifestations like periorificial and acral dermatitis can indicate nutritional deficiencies such as zinc, biotin, protein, or essential fatty acid deficiency, even in developed countries. Early diagnosis is key, especially in children with failure to thrive.

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Area of Science:

  • Dermatology
  • Nutritional Science
  • Pediatrics

Background:

  • Nutritional deficiencies are common in developing nations and can also occur in developed countries due to genetic or acquired conditions.
  • The skin frequently exhibits early signs of nutritional deficiency, serving as a diagnostic indicator.
  • Recent research expands the understanding of at-risk populations beyond poverty, including premature infants and individuals with specific medical conditions.

Purpose of the Study:

  • To review common nutritional deficiencies presenting with periorificial and/or acrodermatitis.
  • To highlight skin manifestations as crucial diagnostic clues for nutritional deficiencies.

Main Methods:

  • Literature review of common nutritional deficiencies causing specific skin conditions.
  • Synthesis of recent findings on at-risk populations and genetic factors.

Main Results:

  • Common deficiencies include zinc, biotin, protein (kwashiorkor), and essential fatty acids.
  • At-risk groups encompass premature infants, patients on long-term total parenteral nutrition, and those with conditions like Crohn's disease, cystic fibrosis, and eating disorders.
  • Genetic factors in inherited deficiencies, such as acrodermatitis enteropathica, are increasingly recognized.

Conclusions:

  • Skin findings, particularly periorificial or acral dermatitis, can guide the diagnosis of nutritional deficiencies.
  • In pediatric cases, consider zinc, biotin, protein, or essential fatty acid deficiency, especially with concurrent failure to thrive.