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Related Concept Videos

Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...

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Related Experiment Video

Updated: Jun 18, 2026

The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy
07:51

The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy

Published on: June 1, 2019

Breast sentinel node imaging with low-dose SPECT/CT.

J P Coffey1, J C Hill

  • 1Royal Preston Hospital, Sharoe Green Lane, Fulwood, Preston, Lancashire, UK. John.Coffey@lthtr.nhs.uk

Nuclear Medicine Communications
|December 8, 2009
PubMed
Summary
This summary is machine-generated.

Single-photon emission computed tomography/computed tomography (SPECT/CT) lymphscintigraphy effectively identifies sentinel lymph nodes (SLNs) in breast cancer patients, with a low false-negative rate of 5.3%. This technique is practical for widespread clinical use in SLN biopsy quality control.

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Published on: October 20, 2010

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Last Updated: Jun 18, 2026

The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy
07:51

The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy

Published on: June 1, 2019

Multispectral Real-time Fluorescence Imaging for Intraoperative Detection of the Sentinel Lymph Node in Gynecologic Oncology
06:37

Multispectral Real-time Fluorescence Imaging for Intraoperative Detection of the Sentinel Lymph Node in Gynecologic Oncology

Published on: October 20, 2010

Area of Science:

  • Oncology
  • Nuclear Medicine
  • Radiology

Background:

  • Sentinel lymph node (SLN) biopsy is crucial for breast cancer staging.
  • Accurate SLN identification and low false-negative rates are key quality control metrics.
  • Indications for single-photon emission computed tomography/computed tomography (SPECT/CT) lymphscintigraphy require formalization.

Purpose of the Study:

  • To report the false-negative rate of SPECT/CT lymphscintigraphy in identifying SLNs in breast cancer patients.
  • To evaluate the utility of SPECT/CT for preoperative SLN visualization.
  • To assess the potential for broader clinical application of SPECT/CT in SLN biopsy.

Main Methods:

  • 187 female patients with breast carcinoma underwent SPECT/CT after injection of 99mTc sulphur colloid.
  • SPECT/CT scanning was performed 45 minutes post-injection.
  • SLN identification and tracer uptake were assessed.

Main Results:

  • SPECT/CT identified SLNs in 158 out of 187 patients.
  • Twenty-nine patients (15.5%) had no SLNs identified on SPECT/CT.
  • The overall false-negative rate for SPECT/CT was 5.3%, with 10 of the non-visualized SLNs showing metastatic infiltration.

Conclusions:

  • SPECT/CT lymphscintigraphy is a practical and effective method for preoperative SLN visualization in breast cancer.
  • The low false-negative rate supports the wider adoption of SPECT/CT in clinical practice.
  • SPECT/CT offers dual structural and functional imaging advantages for SLN biopsy quality control.