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Atomic Force Microscopy

Atomic Force Microscopy

Atomic force microscopy (AFM) is a type of scanning probe microscopy that can analyze topographic details of various specimens like ceramics, glass, polymers, and biological samples. AFM offers over 1000 times more resolution than the optical imaging system. Images generated from AFM are three-dimensional surface profiles, offering an advantage over the flat, two-dimensional images from other imaging techniques.
The AFM Probe
The probe is regarded as the heart of any AFM setup and comprises the...

Overview of Microscopy Techniques

Overview of Microscopy Techniques

The early pioneers of microscopy opened a window into the invisible world of microorganisms. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes that leveraged nonvisible light, such as fluorescence microscopy that uses an ultraviolet light source and electron microscopy that uses short-wavelength electron beams. These advances significantly improved magnification, image resolution, and contrast. By comparison, the...

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Related Experiment Video

Updated: Jun 18, 2026

Atomic Force Microscopy of Red-Light Photoreceptors Using PeakForce Quantitative Nanomechanical Property Mapping

Atomic Force Microscopy of Red-Light Photoreceptors Using PeakForce Quantitative Nanomechanical Property Mapping

Published on: October 24, 2014

Atomic force microscopy as a tool for atom manipulation.

Oscar Custance¹, Ruben Perez, Seizo Morita

¹National Institute for Materials Science, Tsukuba, Ibaraki, Japan. custance.oscar@nims.go.jp

Nature Nanotechnology

|December 8, 2009

Summary

This summary is machine-generated.

Atomic force microscopy enables precise manipulation of atoms and molecules at room temperature. This technique offers new possibilities for building nanoscale devices, advancing nanotechnology research.

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Last Updated: Jun 18, 2026

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Force Spectroscopy of Single Protein Molecules Using an Atomic Force Microscope

Force Spectroscopy of Single Protein Molecules Using an Atomic Force Microscope

Published on: February 28, 2019

Area of Science:

Surface science
Nanotechnology
Atomic manipulation

Background:

Over 20 years of research focused on atomic/molecular manipulation at surfaces for nanoscale devices.
Scanning tunneling microscopy (STM) was the primary technique, typically requiring cryogenic temperatures.

Purpose of the Study:

To review advancements in atomic and molecular manipulation using atomic force microscopy (AFM).
To discuss the potential of AFM for constructing nanoscale systems at room temperature.

Main Methods:

Utilizing atomic force microscopy (AFM) as a scanning probe technique.
Demonstrating the capability of AFM for positioning single atoms.

Main Results:

AFM can manipulate single atoms and molecules at surfaces.
Successful atomic manipulation achieved even at room temperature, unlike traditional methods.

Conclusions:

Atomic force microscopy presents a significant advancement for nanoscale construction.
This technique opens new avenues for the development of future nanoscale devices.