Design and Synthesis of Imidazopyrimidine Derivatives as Potent iNOS Dimerization Inhibitors
Guo-Hua Chu1, Bertrand Le Bourdonnec, Minghua Gu
1Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, PA 19341, USA.
The Open Medicinal Chemistry Journal
|December 8, 2009
Abstract:
A series of imidazopyrimidine derivatives with the general formula I was synthesized and identified as potent inhibitors of iNOS dimer formation, a prerequisite for proper functioning of the enzyme. Stille and Negishi coupling reactions were used as key steps to form the carbon-carbon bond connecting the imidazopyrimidine core to the central cycloalkenyl, cycloalkyl and phenyl ring templates.
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