Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Hypersensitivity Reactions: Cytolytic Reactions01:01

Hypersensitivity Reactions: Cytolytic Reactions

Type II hypersensitivity involves IgG and IgM antibodies targeting cell surface antigens, leading to cell destruction. This can occur through complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), or acting as opsonins for phagocytosis. When excessive, these reactions cause significant tissue damage.Drug-induced hemolytic anemia is a common example, where drugs like penicillin or cephalosporins bind to red blood cells, forming drug-protein complexes. These complexes...
Drug toxicity: Idiosyncratic Reactions01:16

Drug toxicity: Idiosyncratic Reactions

Idiosyncratic drug reactions represent abnormal chemical responses that vary significantly among individuals, ranging from extreme sensitivity to low doses to insensitivity to high doses. These reactions often occur due to the drug's covalent binding with serum proteins, forming a foreign hapten that triggers an immunotoxicological response. The variability in drug reactions has a strong pharmacogenetic foundation, with genetic differences crucial in how individuals metabolize drugs. For...
Drug Toxicity: Overview01:00

Drug Toxicity: Overview

Drug toxicity quantifies the harm a compound causes to an organism, varying by dose and potentially impacting whole systems or specific organs like the liver. Toxic reactions may arise from venomous insect or spider bites, with effects ranging from mild symptoms to severe outcomes such as brain damage or death. Common forms of acute poisoning include ethanol intoxication and overdose of pain or fever medications, with substances like GHB and heroin being particularly lethal at doses close to...
Pharmacovigilance01:19

Pharmacovigilance

Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Childhood Leprosy in Postelimination Era: A Clinico-Epidemiological Prospective Observational Study from India.

Indian dermatology online journal·2023
Same author

Psoriasis as Wolf 's isotopic response over BCG scar.

Indian journal of dermatology, venereology and leprology·2021
Same author

Pyodermatitis-pyostomatitis Vegetans.

Indian journal of dermatology·2017
Same author

Periorbital Varicella Gangrenosa.

Indian journal of dermatology·2016
Same author

Dermatitis artefacta.

Indian journal of psychiatry·2013
Same author

Ichthyosis hystrix.

Indian dermatology online journal·2013

Related Experiment Video

Updated: Jun 18, 2026

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
07:22

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis

Published on: March 14, 2025

Adverse cutaneous drug reaction.

Surajit Nayak1, Basanti Acharjya

  • 1Department of Skin and VD, MKCG Medical College and Hospital, Berhampur, Orissa, India. surajitnyk@yahoo.co.in

Indian Journal of Dermatology
|December 8, 2009
PubMed
Summary
This summary is machine-generated.

Adverse cutaneous drug reactions (ACDR) are common but often unreported, making early diagnosis crucial. This focuses on understanding ACDR mechanisms and diagnostic approaches for better patient management.

Keywords:
ACDRSteven Johnson syndromeadverse drug reactionstoxic epidermal necrolysis

More Related Videos

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Related Experiment Videos

Last Updated: Jun 18, 2026

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
07:22

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis

Published on: March 14, 2025

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Area of Science:

  • Dermatology
  • Clinical Pharmacology
  • Internal Medicine

Background:

  • Adverse cutaneous drug reactions (ACDR) are frequently encountered by physicians in daily practice.
  • Many ACDR cases are underreported, leading to a lack of comprehensive data on incidence, severity, and health outcomes.
  • The continuous introduction of new drugs increases the potential for novel or undocumented drug reactions.

Purpose of the Study:

  • To emphasize the importance of early identification and management of ACDR.
  • To highlight the challenges in diagnosing ACDR, especially in patients with multiple medications.
  • To focus on the pathomechanism and diagnostic approach for ACDR.

Main Methods:

  • Clinical observation and judgment are the primary methods for diagnosing ACDR.
  • Understanding the pathomechanism of drug-host interactions is key.
  • The discussion centers on diagnostic strategies rather than specific treatments.

Main Results:

  • Diagnosis of ACDR is primarily based on clinical judgment due to complex presentations and limited confirmatory testing.
  • Early identification and withdrawal of the offending drug are critical for preventing severe reactions.
  • Familiarity with ACDR presentation and diagnostic approaches is essential for all physicians.

Conclusions:

  • Physicians must be equipped to diagnose and manage ACDR effectively.
  • A thorough understanding of ACDR pathomechanisms aids in diagnosis.
  • Clinical judgment remains the cornerstone for diagnosing ACDR in complex cases.