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Related Experiment Video

Updated: Jun 18, 2026

Fluorescence detection methods for microfluidic droplet platforms
14:16

Fluorescence detection methods for microfluidic droplet platforms

Published on: December 10, 2011

Fluorimetric lead detection in a microfluidic device.

Liyun Zhao1, Ting Wu, Jean-Pierre Lefèvre

  • 1PPSM, ENS Cachan, CNRS, Wilson, 94230, Cachan, France.

Lab on a Chip
|December 8, 2009
PubMed
Summary
This summary is machine-generated.

A novel microfabricated device offers selective lead detection in water using a fluorescent sensor (Calix-DANS4). This sensor achieves a low detection limit of 5 parts per billion (ppb) for lead contamination.

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Area of Science:

  • Analytical Chemistry
  • Microfluidics
  • Sensor Technology

Background:

  • Lead contamination in water poses significant health risks.
  • Accurate and sensitive detection methods are crucial for water quality monitoring.
  • Existing methods may lack selectivity or require complex instrumentation.

Purpose of the Study:

  • To develop a microfabricated device for selective lead detection in water.
  • To utilize a novel fluorescent molecular sensor (Calix-DANS4) for enhanced sensitivity.
  • To establish a low detection limit for lead in aqueous samples.

Main Methods:

  • Fabrication of a Y-shape microchannel device on a glass substrate with a passive mixer.
  • Integration of a selective fluorescent sensor (Calix-DANS4) for lead complexation.
  • Optical detection using UV LEDs for excitation and a photomultiplier for signal collection.

Main Results:

  • Optimization of microcircuit length for efficient Calix-DANS4 complexation.
  • Demonstrated selective detection of lead with a detection limit of 5 ppb.
  • Evaluated the impact of interfering cations, such as calcium.
  • Validated results using Anodic Stripping Voltammetry (ASV).

Conclusions:

  • The microfabricated device provides a sensitive and selective method for lead detection in water.
  • The Calix-DANS4 sensor integrated into the microchip shows high performance.
  • This technology offers a promising solution for real-time water quality monitoring.