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Related Experiment Videos

Elevated central venous pressure: a consequence of exercise training-induced hypervolemia?

V A Convertino1, G W Mack, E R Nadel

  • 1Biomedical Operations and Research Office, National Aeronautics and Space Administration, Kennedy Space Center, Florida 32899.

The American Journal of Physiology
|February 1, 1991
PubMed
Summary

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Exercise training increases blood volume and central venous pressure (CVP) proportionally in men. This maintains vascular capacitance despite hypervolemia, with no changes in key hormones.

Area of Science:

  • Cardiovascular Physiology
  • Exercise Science
  • Sports Medicine

Background:

  • Exercise training is known to induce physiological adaptations.
  • Hypervolemia, an increase in blood volume, is a common adaptation to endurance training.
  • The impact of training-induced hypervolemia on vascular capacitance and related pressures requires further investigation.

Purpose of the Study:

  • To investigate whether exercise training-induced hypervolemia alters total vascular capacitance.
  • To examine the relationship between changes in blood volume and central venous pressure (CVP) post-training.
  • To assess resting levels of key hormones (arginine vasopressin, atrial natriuretic peptide, aldosterone, norepinephrine) after exercise training.

Main Methods:

  • Measurements of resting blood volumes and arterial/central venous pressures in 14 men before and after a 10-week exercise intervention.
Keywords:
NASA Center KSCNASA Discipline CardiopulmonaryNASA Discipline Number 14-10NASA Program Space Physiology and Countermeasures

Related Experiment Videos

  • Control group of 7 subjects who did not undergo exercise.
  • Analysis of plasma hormone levels (AVP, ANP, Ald, NE) at rest.

    • Main Results:

    • Exercise training resulted in a 9% increase in blood volume and a 16% increase in resting CVP.
    • A significant positive linear relationship was found between the percent change in blood volume and CVP.
    • No significant changes were observed in mean arterial blood pressure or plasma levels of AVP, ANP, Ald, and NE.
    • The volume-to-pressure ratio remained unchanged, indicating stable vascular capacitance.

    Conclusions:

    • Exercise training-induced hypervolemia leads to a proportional increase in central venous pressure.
    • Total effective venous capacitance is maintained despite increased blood volume post-training.
    • Hormonal systems typically involved in volume regulation do not appear to be altered at rest by this training regimen.