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Updated: Jun 18, 2026
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Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome
Published on: July 28, 2023
Microecology, intestinal epithelial barrier and necrotizing enterocolitis.
1Division of Neonatology, Department of Pediatrics, University of Florida at Jacksonville, 655 West 8th Street, Jacksonville, FL 32209, USA. renu.sharma@jax.ufl.edu
Pediatric Surgery International
|December 8, 2009
Summary
Neonatal intestinal barrier (IEB) maturation requires microbial signals. Disruptions in beneficial bacteria colonization, often due to prematurity, can lead to necrotizing enterocolitis (NEC).
Area of Science:
- Microbiology
- Neonatal Physiology
- Immunology
Background:
- The neonatal intestine faces microbial colonization challenges post-birth.
- Microbial signals are crucial for intestinal epithelial barrier (IEB) maturation and function.
- Commensal bacteria regulate immunity and support IEB repair.
Purpose of the Study:
- To describe microbial modulation of IEB functions.
- To explore the relationship between IEB dysfunction and necrotizing enterocolitis (NEC).
Main Methods:
- Review of current literature on intestinal microecology and IEB.
- Analysis of metagenomic data regarding commensal bacteria establishment.
- Examination of factors contributing to IEB dysfunction in NEC.
Main Results:
- Commensal bacteria are essential for IEB maturation and protection against inflammation.
- Pathogenic bacteria or impaired immune responses can trigger NEC.
- Prematurity and intensive care nursery hospitalization disrupt beneficial colonization, leading to IEB dysfunction and NEC.
Conclusions:
- Microbial colonization patterns significantly influence neonatal intestinal health.
- Understanding these microbial interactions is key to preventing NEC.
- Metagenomic insights are advancing the comprehension of IEB development and NEC pathogenesis.
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