Jove
Visualize
Contact Us

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Host Resistance Assays.

Methods in molecular biology (Clifton, N.J.)ยท2018
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 18, 2026

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors
06:02

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors

Published on: September 13, 2018

Viral host resistance studies.

Wendy Jo Freebern

    Methods in Molecular Biology (Clifton, N.J.)
    |December 8, 2009
    PubMed
    Summary
    This summary is machine-generated.

    Preclinical immunotoxicity testing evaluates drug effects on immune health. Host resistance models, particularly rodent influenza, are crucial for assessing a drug

    More Related Videos

    Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy
    08:51

    Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy

    Published on: April 3, 2018

    Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency
    18:10

    Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency

    Published on: June 16, 2011

    Related Experiment Videos

    Last Updated: Jun 18, 2026

    Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors
    06:02

    Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors

    Published on: September 13, 2018

    Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy
    08:51

    Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy

    Published on: April 3, 2018

    Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency
    18:10

    Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency

    Published on: June 16, 2011

    Area of Science:

    • Immunotoxicology
    • Infectious disease modeling
    • Preclinical drug safety

    Background:

    • Assessing drug-induced immune dysfunction is critical for public health.
    • Single immune parameter tests may not accurately reflect overall immune health.
    • Complex immune system interactions necessitate comprehensive testing approaches.

    Purpose of the Study:

    • To evaluate the utility of host resistance models in preclinical immunotoxicity testing.
    • To determine if drugs or toxicants adversely affect immune response to infections.
    • To highlight the application of viral host resistance models in safety assessments.

    Main Methods:

    • Utilized viral host resistance models in rodents and non-human primates.
    • Described various viral models including reovirus, Epstein-Barr virus, and cytomegalovirus.
    • Emphasized the well-characterized rodent influenza model for immunotoxicity assessment.

    Main Results:

    • Host resistance models provide a comprehensive approach to assess net immune health.
    • Rodent influenza models are particularly effective for evaluating immunotoxicity.
    • Viral models demonstrate the impact of toxicants on the host's ability to clear infections.

    Conclusions:

    • Host resistance models are essential for accurate preclinical immunotoxicity testing.
    • Rodent influenza models offer a robust platform for evaluating drug safety related to immune function.
    • Comprehensive assessment is vital to understand drug effects on host defense mechanisms.