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Related Concept Videos

Microbial Interactions: Parasitism01:22

Microbial Interactions: Parasitism

Parasitism is a form of microbial interaction in which parasitic microbes exploit a host organism for nutrients and shelter, often at the host's expense. Unlike mutualistic relationships, where both organisms benefit, parasitism benefits only the parasite and harms the host.Classification of ParasitesMicrobial parasites are broadly classified based on their location relative to the host.Ectoparasites remain on the host’s surface, such as the skin or outer tissues, drawing nutrients...

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Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
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Published on: February 22, 2019

Parasite challenge as host resistance models for immunotoxicity testing.

Robert W Luebke

    Methods in Molecular Biology (Clifton, N.J.)
    |December 8, 2009
    PubMed
    Summary

    Assessing immune function and immunosuppression relies on host resistance assays, like those using Trichinella spiralis infection. These methods evaluate parasite elimination and immune responses to gauge compound effects.

    Area of Science:

    • Immunotoxicology
    • Parasitology
    • Host-pathogen interactions

    Background:

    • Assessing immunosuppressive compounds often uses surrogate endpoints.
    • Host resistance assays are the gold standard for evaluating immune function suppression.
    • Resistance to infection involves complex immune effector pathways.

    Purpose of the Study:

    • To describe methods for assessing host resistance to Trichinella spiralis.
    • To evaluate the impact of potential immunosuppressive compounds on host defense.
    • To provide a gold standard for judging immune suppression at molecular and cellular levels.

    Main Methods:

    • Assessing elimination of adult Trichinella spiralis from the small intestine.
    • Quantifying larval body burdens following infection.

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  • Measuring antibody and lymphocyte responses to parasite antigens.

    • Main Results:

    • Trichinella spiralis resistance assays effectively evaluate whole-animal immune function.
    • Immunosuppression significantly impacts the outcome of Trichinella spiralis infection.
    • Methods allow for detailed assessment of different immune response phases.

    Conclusions:

    • Host resistance assays, particularly using Trichinella spiralis, are crucial for identifying immunosuppressive compounds.
    • These methods provide a comprehensive evaluation of immune function relevant to disease resistance.
    • Understanding immune responses to parasites aids in assessing immunotoxicity.