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Updated: Jun 18, 2026
13:38
Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells
Published on: January 18, 2017
[Research advances in aspirin resistance]
1Department of Hematology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Summary
Aspirin resistance, identified in labs by measuring thromboxane A2, reduces the effectiveness of this common antithrombotic drug. This laboratory resistance is linked to increased vascular events in patients.
Area of Science:
- Cardiovascular Medicine
- Pharmacology
- Hematology
Context:
- Aspirin is a widely used antithrombotic agent.
- Aspirin resistance can limit its clinical effectiveness.
- Laboratory resistance is the common definition of aspirin resistance.
Purpose:
- To define aspirin resistance.
- To explain how aspirin resistance is identified.
- To highlight the clinical relevance of laboratory aspirin resistance.
Summary:
- Aspirin resistance refers to the diminished effectiveness of aspirin.
- It is typically identified through laboratory tests measuring thromboxane A2 or thromboxane-dependent platelet function.
- Clinical studies demonstrate a correlation between laboratory aspirin resistance and adverse vascular events.
Impact:
- Understanding aspirin resistance is crucial for optimizing antithrombotic therapy.
- Identifying patients with aspirin resistance may allow for alternative treatment strategies.
- This research underscores the importance of monitoring treatment efficacy in patients taking aspirin.
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