Dramatic effect of Lewis acids on the rhodium-catalyzed hydroboration of olefins
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Updated: Jun 18, 2026
Characterizing Lewis Pairs Using Titration Coupled with In Situ Infrared Spectroscopy
Published on: February 20, 2020
Christopher J Lata1, Cathleen M Crudden
1Department of Chemistry, Queen's University, 90 Bader Lane, Kingston, Ontario K7L 3N6, Canada.
Abstract:
The addition of Lewis acids such as trispentafluoroboron as cocatalysts has been found to have a dramatic effect on the Rh-catalyzed hydroboration of olefins with pinacol borane. For example, aliphatic olefins do not react at all in noncoordinating solvents, but with the addition of 2% of B(C(6)F(5))(3), the reaction is complete in minutes. Similarly, the reaction of aromatic olefins with HBPin occurs slowly and nonselectively in the absence of B(C(6)F(5))(3), but is accelerated and occurs more selectively in its presence. Preliminary mechanistic studies suggest that the B(C(6)F(5))(3) needs to be present throughout the course of the reaction, not just at the initiation stage, and implicate this species, along with THF, in the heterolytic cleavage of the B-H bond of HBPin.
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