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Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
Published on: June 23, 2019
5-Substituted [1]pyrindine derivatives with antiproliferative activity
Stéphanie Kolb1, Mary-Lorène Goddard, Ali Loukaci
1Laboratoire de Pharmacochimie Moléculaire et Cellulaire, Université Paris Descartes, UFR Biomédicale, 45 rue des Saints-Pères, Paris, F-75006, France; INSERM U648, Paris F-75006, France.
Abstract:
We report herein the synthesis of 5-substituted [1]pyrindine derivatives and the evaluation of their antiproliferative properties on HeLa cells, a cervical carcinoma tumor cell line, and on the melanoma A2058 cell line. The most efficient compounds display cytotoxicity against tumor cells in the micromolar range but have interestingly no effect against the normal human fibroblasts CRL-2796. Generally, these pyrindines are active on both tumor cell lines. Compounds bearing large substituents with structural rigidity at position 5 such as phenyl-furyl show no inhibition of cell growth.
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