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A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
T Sreelatha1, A Hymavathi, V Rama Subba Rao
1Division of Organic Chemistry-I, Natural Product Laboratory, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India.
Bioorganic & Medicinal Chemistry Letters
|December 9, 2009
Summary
Researchers explored Derris scandens roots, discovering a new benzil derivative and ten known compounds. Several compounds showed insect antifeedant and growth inhibitory effects against the castor semilooper pest, Achaea janata.
Area of Science:
- Natural Product Chemistry
- Phytochemistry
- Insect Toxicology
Background:
- Derris scandens is a plant species known for its potential medicinal properties.
- Investigating plant extracts for bioactive compounds is crucial for discovering new pest control agents.
Purpose of the Study:
- To isolate and characterize compounds from the root extract of Derris scandens.
- To evaluate the insect antifeedant and growth inhibitory activities of these compounds against Achaea janata.
Main Methods:
- Bioactivity-guided fractionation of Derris scandens root extract.
- Structure elucidation using spectroscopic techniques (IR, MS, 1D and 2D NMR).
- Laboratory bioassays to assess antifeedant and growth inhibitory effects on Achaea janata.
Main Results:
- A new benzil derivative (derrisione A) and ten known compounds were isolated.
- Several isolates exhibited significant insect feeding deterrence and toxicity.
- Derrisione A showed moderate antifeedant activity (58.6+/-1.7%) against Achaea janata at 10 µg/cm³.
Conclusions:
- Derris scandens root extract contains compounds with potent insecticidal properties.
- The identified compounds, particularly derrisione A, show promise as natural antifeedants for pest management.
- Further research could explore the potential of these compounds for sustainable agriculture.
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