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Experimental Pulmonary Emphysema: The Effect of Intratracheal Injection of Cadmium Chloride Solution in the Guinea

W M Thurlbeck, F D Foley

    The American Journal of Pathology
    |December 9, 2009
    PubMed
    Abstract

    No abstract available in PubMed .

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    Emphysema, a major phenotype of chronic obstructive pulmonary disease (COPD), is characterized by irreversible destruction of alveolar walls and permanent enlargement of distal airspaces. Unlike chronic bronchitis, which primarily affects the airways, emphysema predominantly involves the lung parenchyma, where structural damage leads to airflow limitation.PathophysiologyIt most commonly results from prolonged exposure to cigarette smoke and other toxic gases, particularly cigarette smoke.