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Measurement of capillary filtration coefficient in a solid tumor
1Department of Chemical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213-3890.
Cancer Research
|February 15, 1991
Summary
The capillary filtration coefficient in R3230AC mammary adenocarcinoma tumors is significantly elevated, 10 to 1000 times higher than normal tissues. This finding suggests increased fluid leakage and potential edema in tumors.
Area of Science:
- Oncology
- Vascular Biology
- Biophysics
Background:
- Tumor growth is associated with altered vascular properties.
- Understanding transvascular fluid dynamics is crucial for cancer research and treatment.
Purpose of the Study:
- To quantify the net transvascular filtration rate (JF) in an isolated R3230AC mammary adenocarcinoma tumor.
- To determine the capillary filtration coefficient in this tumor model.
Main Methods:
- Utilized a gravimetric method to monitor tissue weight changes over time.
- Measured JF by altering venous pressure in an isolated, RBC-free perfused tumor model.
Main Results:
- The capillary filtration coefficient was measured at 2.2 ml/min/mm Hg/100 g (range: 0.8-2.8).
- This value is 10 to 1000 times higher than reported for several normal tissues.
- The results fall within the range observed for glomerular capillaries.
Conclusions:
- The elevated capillary filtration coefficient indicates increased vascular permeability in R3230AC mammary adenocarcinoma.
- These findings are consistent with elevated tumor interstitial fluid pressure, flow, and peritumor edema.
- This suggests potential implications for drug delivery and tumor progression.