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Published on: August 30, 2014
Specific immune response in the human respiratory tract following oral immunization with live typhoid vaccine
B D Forrest1, J T LaBrooy, P Robinson
1Department of Medicine, University of Adelaide, Australia.
Abstract:
Specific antibody responses in the lower respiratory tract of human subjects to orally administered Salmonella typhi Ty21a are reported. These responses, predominantly of the immunoglobulin G class, were determined to be a transudate from serum. These results were supported by the similarity in responses to parenteral administration of heat-killed typhoid vaccine. Specific immunoglobulin A antibody was a poor contributor to the respiratory antibody response to either vaccine.
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