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Peripheral diabetic neuropathy treated with amitriptyline and fluphenazine
JAMA
|November 21, 1977
Summary
Diabetic peripheral neuropathy pain is difficult to treat. Fluphenazine hydrochloride and amitriptyline hydrochloride, alone or combined, provided significant pain relief in eight patients, suggesting a potential new treatment option.
Area of Science:
- Neurology
- Pharmacology
Background:
- Diabetic peripheral neuropathy is a common complication of diabetes.
- Pain associated with this condition often proves refractory to conventional therapies.
Observation:
- Eight patients with refractory neuropathic pain were treated with fluphenazine hydrochloride, amitriptyline hydrochloride, or a combination.
- Remarkable pain relief was observed within 2-5 days of treatment initiation.
Findings:
- Fluphenazine hydrochloride and amitriptyline hydrochloride demonstrated significant efficacy in alleviating neuropathic pain.
- Discontinuation of treatment led to pain recurrence, which was reversed upon reintroduction of the medications.
Implications:
- These findings suggest that fluphenazine, alone or with amitriptyline, may offer a novel therapeutic strategy for diabetic peripheral neuropathy pain.
- Further research is warranted to confirm these preliminary results and explore optimal dosing and long-term effects.