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Adriamycin-induced neoplastic lesions in the Egyptian toad Bufo regularis
M M el-Mofty1, V V Khudoley, S A Sakr
1Department of Zoology, Faculty of Science, University of Alexandria, Egypt.
Oncology
|January 1, 1991
Abstract:
Injecting adult toads (Bufo regularis) subcutaneously in the dorsal lymph sac with adriamycin at a dose of 2 mg/kg body weight, once every 3 weeks for 20 weeks, induced hepatocellular carcinomas in 20 out of 100 animals. Metastases of the primary liver tumors appeared in the kidneys of 7 toads.