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Mutagenicity of 3-nitrodibenzofuran and 3-aminodibenzofuran
Y Uno1, H Matsushita, T Uehiro
1Chemistry and Physics Division, National Institute for Environmental Studies, Ibaraki, Japan.
Toxicology Letters
|January 1, 1991
Abstract:
Mutagenicities of 3-nitrodibenzofuran and 3-aminodibenzofuran were examined using Salmonella typhimurium TA98 and TA100. Strong mutagenicity was found in both compounds. The mutagenic potency of 3-nitrodibenzofuran was approximately 3.5-fold stronger in TA98 and twice stronger in TA100 than that of benzo[a]pyrene. Mutagenicity of 3-aminodibenzofuran was observed under metabolic activation and was 10 times stronger in TA98 and about 5 times stronger in TA100 than that of benzo[a]pyrene.