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Inflammatory breast cancer.

M P Moore1, J K Ihde, J P Crowe

  • 1Memorial Sloan Kettering Cancer Center, New York, NY 10021.

Archives of Surgery (Chicago, Ill. : 1960)
|March 11, 1991
PubMed
Summary
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Inflammatory breast cancer historically has a poor prognosis. This review found 5-year survival at 45% and disease-free survival at 37% for patients treated with combination chemotherapy.

Area of Science:

  • Oncology
  • Medical Research

Background:

  • Inflammatory breast cancer (IBC) historically presents a poor prognosis.
  • Recent treatment strategies aim to improve outcomes for IBC patients.

Purpose of the Study:

  • To evaluate the Memorial Sloan-Kettering Cancer Center's recent experience with inflammatory breast cancer.
  • To assess the role of combination chemotherapy in treating IBC.
  • To compare the impact of surgery and radiation on local/regional failure in IBC.

Main Methods:

  • Retrospective review of 56 patients diagnosed with local/regional inflammatory breast cancer between 1975 and 1984.
  • All patients received combination chemotherapy.
  • Analysis of treatment sequences including induction chemotherapy followed by mastectomy and adjuvant chemotherapy versus mastectomy followed by chemotherapy.

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Main Results:

  • Overall 5-year survival rate was 45%; 5-year disease-free survival rate was 37%.
  • Patients receiving induction chemotherapy followed by mastectomy and adjuvant chemotherapy had similar survival and disease-free survival rates compared to those treated with mastectomy followed by chemotherapy.
  • Residual cancer was found in all 21 patients treated with induction chemotherapy, with extensive disease in 18.
  • The local/regional failure rate was 34%.

Conclusions:

  • Combination chemotherapy demonstrates a 45% 5-year survival rate for inflammatory breast cancer.
  • Neoadjuvant chemotherapy followed by surgery and adjuvant chemotherapy did not significantly improve survival outcomes compared to other treatment sequences.
  • High rates of residual disease after induction chemotherapy highlight the aggressive nature of inflammatory breast cancer.