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Related Experiment Videos

Nerve function in workers with long term exposure to trichloroethene.

M W Ruijten1, M M Verberk, H J Sallé

  • 1Coronel Laboratory, Faculty of Medicine, University of Amsterdam, The Netherlands.

British Journal of Industrial Medicine
|February 1, 1991
PubMed
Summary

Long-term trichloroethene exposure may subtly impact trigeminal and sural nerves, particularly the refractory period, indicating preclinical neuropathy in printing workers. Further research is needed.

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Area of Science:

  • Neuroscience
  • Occupational Health
  • Toxicology

Background:

  • Occupational exposure to trichloroethene (TCE) is common in printing industries.
  • Potential neurotoxic effects of TCE require further investigation, especially in long-term exposure scenarios.

Purpose of the Study:

  • To evaluate the effects of chronic trichloroethene exposure on specific nervous system functions in printing workers.
  • To identify sensitive indicators of preclinical toxic neuropathy.

Main Methods:

  • Nerve conduction studies (sural and peroneal nerves) including conduction velocity, response amplitude, and refractory period.
  • Assessment of trigeminal nerve function via masseter and blink reflex latencies.
  • Evaluation of autonomic nerve function through heart rate response to isometric exercise and deep breathing.

Related Experiment Videos

  • Calculation of individual cumulative TCE exposure and analysis using multiple linear regression.

    • Main Results:

    • A slight reduction in sural nerve conduction velocity (SNCV) and a prolongation of the sural nerve refractory period (SRP) were observed.
    • Increased latency of the masseter reflex, suggesting trigeminal nerve involvement.
    • No significant changes were found in blink reflex, motor nerve function, or autonomic nerve function.
    • Refractory period emerged as a sensitive indicator of preclinical neuropathy.

    Conclusions:

    • Chronic exposure to trichloroethene, even at threshold limit values, may lead to subtle, preclinical neuropathic changes in the trigeminal and sural nerves.
    • The refractory period is a promising biomarker for early detection of TCE-induced neurotoxicity.